Étudiante-chercheure étoile December 2016

Pauline Rullière

Postdoctoral fellow in Chemistry
Université de Montréal

Award-winning publication: Difluorocarbene Addition to Alkenes and Alkynes in Continuous Flow

Published in: Organic Letters


Today, it is no longer enough to produce molecules efficiently. New molecules must also be produced ecologically, using fewer atoms and solvents and less energy. The research conducted by Pauline Rullière and her team reveals that continuous flow chemistry technology enables the use of reagents that are not available at the industrial scale for safety reasons. With continuous flow synthesis, temperature, pressure and response times are precisely controlled. The researchers demonstrated that it is possible to generate difluorocarbene—a highly reactive intermediary—and avoid degradation in stable pressure and temperature conditions. The technology supports the large-scale green synthesis of high-potential molecules in the pharmaceutical and new materials sectors.