Relève étoile Louis-Berlinguet 
July 2019

Christopher Bérubé

PhD student in Chemistry
Université Laval

Award-winning publication: A novel route towards cycle-tail peptides using oxime resin: teaching an old dog a new trick

Published in: Organic & Biomolecular Chemistry


What do oxytocin and cyclosporin have in common? They belong to the same class of cyclic peptide therapeutics that are administered to millions of patients every day! Indeed, there are hundreds of natural cyclic peptides with strong therapeutic potential. But, to develop drugs, large volumes of the substances are required. Christopher Bérubé's discovery now provides quick access to myriads of cyclic peptides by relying on resin as a solid support to increase the speeds and yields of the different synthesis phases. It clears the way to study and produce many new drugs for a range of applications.